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My friend Josh has told me numerous times that Django is much easier to work with on Linux. Basically things are easier if you know how to do them. Whether things are easier to learn or not on Linux compared to other OS's is debatable. But, on this point anyway, it seems that Linux and Django really play well together.

Almost any interesting application nowadays uses a database to store its goodies. One of the most popular is the wildly-successful and generally good-looking MySQL database. Hopefully it stays true to its core (and free!) now that Sun has acquired it. Here's a tidbit on how to get it running on Ubuntu.